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It can exist in different redox states (FADH2, FADH).[ref] Within the mitochondria, FAD and FMN also act as antioxidants, integral to activating the various enzymes that protect cells from oxidative stress, thus making adequate riboflavin essential for healthy mitochondria

Upon receiving apoptotic signals, caspase-8, as a key protease initiating apoptosis, is activated [77]

A wide variety of danger signals (exogenous, endogenous or damages associated with specific molecula pathways) activate the NLRP3 inflammasome

Peptidergic neurons of the Edinger-Westphal nucleus express TRPA1 ion channel that is downregulated both upon chronic variable mild stress in male mice and in humans who died by suicide